Chemotherapy-Induced Neutropenia as a Prognostic Factor in Patients With Advanced Epithelial Ovarian Carcinoma.

ABSTRACT:

Background

To evaluate the prognostic value of chemotherapy-induced neutropenia (CIN) in epithelial ovarian carcinoma (EOC) treated with primary surgery followed by platinum-based chemotherapy.

Methods

The records of primary EOC treated between Jan 1^st 2002 and Dec 31^st 2016 were reviewed according to the including and excluding criteria. CIN was defined as absolute neutrophil count (ANC) after chemotherapy <2.0 × 10⁹/L. Patients with CIN were further divided into mild and severe CIN (ANC <1.0 × 10⁹/L), early-onset and late-onset (>3 cycles) CIN. Clinical characteristic was compared by chi-square test. Overall survival (OS) and progression-free survival (PFS) were compared using Kaplan-Meier analysis, univariate and multivariate Co

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10328011 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature