Gene Signatures for Latent Radiation-Induced Lung Injury Post X-ray Exposure in Mouse.

ABSTRACT:

Objective

To investigate the X-ray-specific sensitive genes and potential signaling pathways involved in the latent period of radiation-induced lung injury (RILI) in mouse models.

Method

Mice were randomized into groups for whole thoracic irradiation with a single fraction of 20 Gy X-ray or 12.5 Gy carbon heavy ion. Lungs were harvested 3 weeks after the irradiation, whole RNA was extracted and detected with the genome-wide transcriptional microarrays. Differentially expressed genes (DEGs) were calculated for each group and the X-ray-specific sensitive genes were determined, followed by the gene enrichment analysis of those DEGs exploring the potentially relevant signaling pathways and biological processes in latent RILI.

Results

Three weeks after irradiation, gene ex

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10328036 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature