Potentiation of neuronal activity by tonic GluD1 current in brain slices.

ABSTRACT: Ion channel function of native delta glutamate receptors (GluD_R ) is incompletely understood. Previously, we and others have shown that activation of Gαq protein-coupled receptors (GqPCR) produces a slow inward current carried by GluD1_R . GluD1_R also carries a tonic cation current of unknown cause. Here, using voltage-clamp electrophysiological recordings from adult mouse brain slices containing the dorsal raphe nucleus, we find no role of ongoing G-protein-coupled receptor activity in generating or sustaining tonic GluD1_R currents. Neither augmentation nor disruption of G protein activity affects tonic GluD1_R currents, suggesting that ongoing G-protein-coupled receptor activity does not give rise to tonic GluD1_R currents. F

SUBMITTER: Copeland DS 

PROVIDER: S-EPMC10328076 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature