M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats.

ABSTRACT: In the central nervous system, the formation of fibrotic scar after injury inhibits axon regeneration and promotes repair. However, the mechanism underlying fibrotic scar formation and regulation remains poorly understood. M2 macrophages regulate fibrotic scar formation after injury to the heart, lung, kidney, and central nervous system. However, it remains to be clarified whether and how M2 macrophages regulate fibrotic scar formation after cerebral ischemia injury. In this study, we found that, in a rat model of cerebral ischemia induced by middle cerebral artery occlusion/reperfusion, fibrosis and macrophage infiltration were apparent in the ischemic core in the early stage of injury (within 14 days of injury). The number of infiltrated macrophages was positively correlated with fibrone

SUBMITTER: Huang JG 

PROVIDER: S-EPMC10328259 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature