Nanotechnology-based gene therapy as a credible tool in the treatment of Alzheimer's disease.

ABSTRACT: Toxic aggregated amyloid-β accumulation is a key pathogenic event in Alzheimer's disease. Treatment approaches have focused on the suppression, deferral, or dispersion of amyloid-β fibers and plaques. Gene therapy has evolved as a potential therapeutic option for treating Alzheimer's disease, owing to its rapid advancement over the recent decade. Small interfering ribonucleic acid has recently garnered considerable attention in gene therapy owing to its ability to down-regulate genes with high sequence specificity and an almost limitless number of therapeutic targets, including those that were once considered undruggable. However, lackluster cellular uptake and the destabilization of small interfering ribonucleic acid in its biological environment restrict its therapeutic application, nece

SUBMITTER: Unnisa A 

PROVIDER: S-EPMC10328264 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature