The role of manganese in morphogenesis and pathogenesis of the opportunistic fungal pathogen Candida albicans.

ABSTRACT: Metals such as Fe, Cu, Zn, and Mn are essential trace nutrients for all kingdoms of life, including microbial pathogens and their hosts. During infection, the mammalian host attempts to starve invading microbes of these micronutrients through responses collectively known as nutritional immunity. Nutritional immunity for Zn, Fe and Cu has been well documented for fungal infections; however Mn handling at the host-fungal pathogen interface remains largely unexplored. This work establishes the foundation of fungal resistance against Mn associated nutritional immunity through the characterization of NRAMP divalent metal transporters in the opportunistic fungal pathogen, Candida albicans. Here, we identify C. albicans Smf12 and Smf13 as two NRAMP transporters required for cellular Mn accumulati

SUBMITTER: Wildeman AS 

PROVIDER: S-EPMC10328360 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature