Immune microenvironment analysis and novel biomarkers of early-stage lung adenocarcinoma evolution.

ABSTRACT:

Background

Lung cancer is the deadliest and most diagnosed type of cancer worldwide. The 5-year survival rate of lung adenocarcinoma (LUAD) dropped significantly when tumor stages advanced. Patients who received surgically resecting at the pre-invasive stage had a 5-year survival rate of nearly 100%. However, the study on the differences in gene expression profiles and immune microenvironment among pre-invasive LUAD patients is still lacking.

Methods

In this study, the gene expression profiles of three pre-invasive LUAD stages were compared using the RNA-sequencing data of 10 adenocarcinoma in situ (AIS) samples, 12 minimally invasive adenocarcinoma (MIA) samples, and 10 invasive adenocarcinoma (IAC) samples.

Results

The high expression levels of PTGFRN (Hazard Ratio

SUBMITTER: Liu J 

PROVIDER: S-EPMC10328385 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature