Brain perivascular spaces and autism: clinical and pathogenic implications from an innovative volumetric MRI study.

ABSTRACT:

Introduction

Our single-center case-control study aimed to evaluate the unclear glymphatic system alteration in autism spectrum disorder (ASD) through an innovative neuroimaging tool which allows to segment and quantify perivascular spaces in the white matter (WM-PVS) with filtering of non-structured noise and increase of the contrast-ratio between perivascular spaces and the surrounding parenchyma.

Methods

Briefly, files of 65 ASD and 71 control patients were studied. We considered: ASD type, diagnosis and severity level and comorbidities (i.e., intellectual disability, attention-deficit hyperactivity disorder, epilepsy, sleep disturbances). We also examined diagnoses other than ASD and their associated comorbidities in the control group.

Results

When males and femal

SUBMITTER: Sotgiu MA 

PROVIDER: S-EPMC10328421 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature