Deep multi-omics integration by learning correlation-maximizing representation identifies prognostically stratified cancer subtypes.

ABSTRACT:

Motivation

Molecular subtyping by integrative modeling of multi-omics and clinical data can help the identification of robust and clinically actionable disease subgroups; an essential step in developing precision medicine approaches.

Results

We developed a novel outcome-guided molecular subgrouping framework, called Deep Multi-Omics Integrative Subtyping by Maximizing Correlation (DeepMOIS-MC), for integrative learning from multi-omics data by maximizing correlation between all input -omics views. DeepMOIS-MC consists of two parts: clustering and classification. In the clustering part, the preprocessed high-dimensional multi-omics views are input into two-layer fully connected neural networks. The outputs of individual networks are subjected to Generalized Canonical Correlat

SUBMITTER: Ji Y 

PROVIDER: S-EPMC10328436 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature