A cell membrane model that reproduces cortical flow-driven cell migration and collective movement.

ABSTRACT: Many fundamental biological processes are dependent on cellular migration. Although the mechanical mechanisms of single-cell migration are relatively well understood, those underlying migration of multiple cells adhered to each other in a cluster, referred to as cluster migration, are poorly understood. A key reason for this knowledge gap is that many forces-including contraction forces from actomyosin networks, hydrostatic pressure from the cytosol, frictional forces from the substrate, and forces from adjacent cells-contribute to cell cluster movement, making it challenging to model, and ultimately elucidate, the final result of these forces. This paper describes a two-dimensional cell membrane model that represents cells on a substrate with polygons and expresses various mechanical forc

SUBMITTER: Sato K 

PROVIDER: S-EPMC10328438 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature