Mechanistic insights into robust cardiac I_Ks potassium channel activation by aromatic polyunsaturated fatty acid analogues.

ABSTRACT: Voltage-gated potassium (K_V) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. K_V channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for example, result in membrane hyperexcitability, a characteristic of epilepsy and cardiac arrhythmias. Interventions intended to restore K_V channel function have strong therapeutic potential in such disorders. Polyunsaturated fatty acids (PUFAs) and PUFA analogues comprise a class of K_V channel activators with potential applications in the treatment of arrhythmogenic disorders such as long QT syndrome (LQTS). LQTS is caused by a loss-of-function of the cardiac I_Ks channel - a tetrameric pota

SUBMITTER: Bohannon BM 

PROVIDER: S-EPMC10328494 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature