Potential Benefit of Probiotic E. Coli Nissle in Term Neonates.

ABSTRACT:

Background

 Probiotics are often viewed as an immunity enhancing agent. The objective of this study was to investigate whether oral administration of Escherichia coli Nissle 1917 reduces the number of infections, their duration, and severity in the first 24 months after parturition in healthy neonates.

Subjects and methods

 This prospective, confirmatory, randomised, double-blind, placebo-controlled study enrolled 567 healthy neonates from four German and two Polish sites. Neonates received 10e8 viable E. coli Nissle (n=283) or placebo (n=284) daily in the first week and every second day in week 2 and 3. After 6 and 12 months, the subjects received additional instillations on ten subsequent days. The overall efficacy was assessed by the number of infections per observation p

SUBMITTER: Olbertz D 

PROVIDER: S-EPMC10328724 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature