Surface proteins of Shiga toxin-producing Escherichia coli mediate association with milk fat globules in raw milk.

ABSTRACT:

Introduction

By adhering to host cells and colonizing tissues, bacterial pathogens can successfully establish infection. Adhesion is considered the first step of the infection process and bacterial adhesion to anti-adhesive compounds is now seen as a promising strategy to prevent infectious diseases. Among the natural sources of anti-adhesive molecules, the membrane of milk fat globules (MFGs) is of interest because of its compositional diversity of proteins and glycoconjugates. However, few studies have focused on the bacterial molecules involved in MFG- mediated inhibition of bacterial adhesion to enterocytes.

Methods

We used three pathogenic Shiga toxin-producing Escherichia coli (STEC) strains (O26:H11 str. 21765, O157:H7 str. EDL933, and O103:H3 str. PMK5) as models to

SUBMITTER: Bagel A 

PROVIDER: S-EPMC10328742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature