A genetically supported drug repurposing pipeline for diabetes treatment using electronic health records.

ABSTRACT:

Background

The identification of new uses for existing drug therapies has the potential to identify treatments for comorbid conditions that have the added benefit of glycemic control while also providing a rapid, low-cost approach to drug (re)discovery.

Methods

We developed and tested a genetically-informed drug-repurposing pipeline for diabetes management. This approach mapped genetically-predicted gene expression signals from the largest genome-wide association study for type 2 diabetes mellitus to drug targets using publicly available databases to identify drug-gene pairs. These drug-gene pairs were then validated using a two-step approach: 1) a self-controlled case-series (SCCS) using electronic health records from a discovery and replication population, and 2) Mendelian

SUBMITTER: Shuey MM 

PROVIDER: S-EPMC10328805 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature