Sources of gut microbiota variation in a large longitudinal Finnish infant cohort.

ABSTRACT:

Background

Although the infant gut microbiota has been extensively studied, comprehensive assessment on the microbiota determinants including technical variables has not been performed in large infant cohorts.

Methods

We studied the effect of 109 variables on the 16S rRNA gene amplicon-based gut microbiota profiles of infants sampled longitudinally from three weeks to two years of life in the Finnish HELMi birth cohort. Spot faecal samples from both parents were included for intra-family analyses, totalling to 7657 samples from 985 families that were evaluated for beta-diversity patterns using permutational multivariate analysis on Bray-Curtis distances, and differential abundance testing and alpha-diversity for variables of interest. We also assessed the effect of different

SUBMITTER: Jokela R 

PROVIDER: S-EPMC10328818 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature