Cost-Effectiveness and Budget Impact of a Novel Antithrombotic Drug Removal System to Reduce Bleeding Risk in Patients on Preoperative Ticagrelor Undergoing Cardiac Surgery.

ABSTRACT:

Background

Antithrombotic drugs, including the P2Y₁₂ inhibitor ticagrelor, increase the risk of perioperative bleeding in patients requiring urgent cardiac surgery. Perioperative bleeding can lead to increased mortality and prolong intensive care unit and hospital stays. A novel sorbent-filled hemoperfusion cartridge that intraoperatively removes ticagrelor via hemoadsorption can reduce the risk of perioperative bleeding. We estimated the cost-effectiveness and budget impact of using this device versus standard practices to reduce the risk of perioperative bleeding during and after coronary artery bypass grafting from the US healthcare sector perspective.

Methods

We used a Markov model to analyze the cost-effectiveness and budget impact of the hemoadsorption devic

SUBMITTER: Cohen BG 

PROVIDER: S-EPMC10328880 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature