Pregnancy outcomes in women with a mitral valve prosthesis: A systematic review and meta-analysis.

ABSTRACT:

Objectives

To evaluate the ongoing debate concerning the choice of valve prosthesis for women requiring mitral valve replacement (MVR) and who wish to conceive. Bioprostheses are associated with risk of early structural valve deterioration. Mechanical prostheses require lifelong anticoagulation and carry maternal and fetal risks. Also, the optimal anticoagulation regimen during pregnancy after MVR remains unclear.

Methods

A systematic review and meta-analysis was conducted of studies reporting on pregnancy after MVR. Valve- and anticoagulation-related maternal and fetal risks during pregnancy and 30 days' postpartum were analyzed.

Results

Fifteen studies reporting 722 pregnancies were included. In total, 87.2% of pregnant women had a mechanical prosthesis and 12.5% a

SUBMITTER: Grashuis P 

PROVIDER: S-EPMC10328972 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature