Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes.

ABSTRACT: Parkinson´s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Aggravation of symptoms is mirrored by accumulation of protein aggregates mainly composed by alpha-synuclein in different brain regions, called Lewy bodies (LB). Previous studies have identified several molecular mechanisms as autophagy and inflammation playing a role in PD pathogenesis. Increased insights into mechanisms involved in early disease stages and driving the progression of the LB pathology are required for the development of disease-modifying strategies. Here, we aimed to elucidate disease stage-specific transcriptomic changes in brain tissue of well-characterized PD and control donors. We collected frontal cortex samples from 84 donors and sequenced both the

SUBMITTER: Cappelletti C 

PROVIDER: S-EPMC10329075 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature