Association of vitamin D levels and VDR variant (rs2228570) with allergic rhinitis: A meta-analysis and trial sequential analysis.

ABSTRACT:

Background

Allergic rhinitis (AR) is a most common allergic condition characterised by cough, sneezing and flu-like symptoms. The aetiology of AR is not known. A deficiency of vitamin D has been associated with various allergic diseases. The role of vitamin D in allergic rhinitis has been explored in different populations, but the results remained inconsistent. Furthermore, vitamin D exerts its effect through the vitamin D receptor (VDR), and genetic variations in the VDR gene significantly alter vitamin D. We performed a meta-analysis to investigate the role of vitamin D levels and VDR polymorphisms with a predisposition to the development of AR.

Materials and methods

All published articles were searched using databases such as PubMed, Google Scholar, and Science Direct. Ba

SUBMITTER: Ju F 

PROVIDER: S-EPMC10329122 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature