CircSnd1 promotes atherosclerosis progression through the miR-485-3p/Olr1 signaling pathway.

ABSTRACT:

Background

Circular RNAs (circRNAs) participate in the development of atherosclerotic cardiovascular disease. Identifying and verifying the key competing endogenous RNA (ceRNA) network related to atherosclerosis (AS) is significant for understanding the development of AS. The aim of this study was to investigate the circRNA-miRNA‒mRNA network, identify a key circRNA and explore its role in the development of atherosclerosis.

Methods

Differentially expressed mRNAs (DEMs) and circRNAs (DECs) in the AS model were obtained from datasets in the Gene Expression Omnibus (GEO) database. R software and Cytoscape software were used to construct and visualize the ceRNA network. The dual-luciferase reporter experiment and the RNA pull-down experiment were used to verify the selected ceR

SUBMITTER: Yang L 

PROVIDER: S-EPMC10329125 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature