Prognostic factors and clinical outcomes of breast cancer patients with disease progression during neoadjuvant systemic therapy.

ABSTRACT:

Background

Disease progression during neoadjuvant systemic therapy for breast cancer indicates poor prognosis, while predictors of the clinical outcomes of these patients remain unclear. By comparing the clinical outcomes of patients with different patterns of salvage treatment strategies, we try to evaluate the factors predicting distant failure and explore the favourable treatment for them.

Methods

Patients with disease progression during neoadjuvant systemic therapy for stage I-III breast cancer diagnosed between January 1, 2008 and July 31, 2021 in Fudan University Shanghai Cancer Center were enrolled. Disease progression was defined as at least a 20% increase in the sum of diameters of target lesions or the appearance of new breast or nodal lesions. Kaplan-Meier, univar

SUBMITTER: Ling YX 

PROVIDER: S-EPMC10329167 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature