Identification of biomarkers and immune infiltration in acute myocardial infarction and heart failure by integrated analysis.

ABSTRACT: The mortality of heart failure after acute myocardial infarction (AMI) remains high. The aim of the present study was to analyze hub genes and immune infiltration in patients with AMI and heart failure (HF). The study utilized five publicly available gene expression datasets from peripheral blood in patients with AMI who either developed or did not develop HF. The unbiased patterns of 24 immune cell were estimated by xCell algorithm. Single-cell RNA sequencing data were used to examine the immune cell infiltration in heart failure patients. Hub genes were validated by quantitative reverse transcription-PCR (RT-qPCR). In comparison with the coronary heart disease (CHD) group, immune infiltration analysis of AMI patients showed that macrophages M1, macrophages, monocytes, natural killer (NK)

SUBMITTER: Liu W 

PROVIDER: S-EPMC10329185 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature