Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies.

ABSTRACT: Chemical risk assessment ensures protection from the toxic effects of drugs and manmade chemicals. To comply with regulatory guidance, studies in complex organisms are required, as well as mechanistic studies to establish the relevance of any toxicities observed to man. Although in vitro toxicity models are improving, in vivo studies remain central to this process. Such studies are invariably time-consuming and often involve large numbers of animals. New regulatory frameworks recommend the implementation of "smart" in vivo approaches to toxicity testing that can effectively assess safety for humans and comply with societal expectations for reduction in animal use. A major obstacle in reducing the animals required is the time-consuming and complexity of the pathological

SUBMITTER: Inesta Vaquera F 

PROVIDER: S-EPMC10329194 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature