Absolute and Relative Risks of Kidney Outcomes Associated With Lithium vs Valproate Use in Sweden.

ABSTRACT:

Importance

Among patients with bipolar disorder, discordant findings have been published on the nephrotoxic effects of lithium therapy.

Objective

To quantify absolute and relative risks of chronic kidney disease (CKD) progression and acute kidney injury (AKI) in people who initiated lithium compared with valproate therapy and to investigate the association between cumulative use and elevated lithium levels and kidney outcomes.

Design, setting, and participants

This cohort study had a new-user active-comparator design and used inverse probability of treatment weights to minimize confounding. Included patients initiated therapy with lithium or valproate from January 1, 2007, to December 31, 2018, and had a median follow-up of 4.5 years (IQR, 1.9-8.0 years). Data analysi

SUBMITTER: Bosi A 

PROVIDER: S-EPMC10329212 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature