The Association of Peripheral and Central Olfaction With Frailty in Older Adults.

ABSTRACT:

Background

Olfactory impairment is increasingly recognized as a biomarker of frailty, but the relationship between olfactory subdomains that describe peripheral or central dysfunction and frailty remains unexplored.

Methods

We examined 1 160 older adults from the National Social Life, Health, and Aging Project Wave 3. Olfactory identification (OI): the ability to identify an odorant; and olfactory sensitivity (OS): the ability to detect the presence of an odorant, were assessed using 5- and 6-point measures, respectively. Frailty was operationalized as both a 37-item frailty index (FI) and the 5-item Physical Frailty Phenotype (PFP). Mixed models were fit to examine the association between OI, OS, FI, and PFP, while adjusting for demographic and clinical covariates.

Resul

SUBMITTER: Nagururu NV 

PROVIDER: S-EPMC10329228 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature