Harmonized multi-metric and multi-centric assessment of EEG source space connectivity for dementia characterization.

ABSTRACT:

Introduction

Harmonization protocols that address batch effects and cross-site methodological differences in multi-center studies are critical for strengthening electroencephalography (EEG) signatures of functional connectivity (FC) as potential dementia biomarkers.

Methods

We implemented an automatic processing pipeline incorporating electrode layout integrations, patient-control normalizations, and multi-metric EEG source space connectomics analyses.

Results

Spline interpolations of EEG signals onto a head mesh model with 6067 virtual electrodes resulted in an effective method for integrating electrode layouts. Z-score transformations of EEG time series resulted in source space connectivity matrices with high bilateral symmetry, reinforced long-range connections, an

SUBMITTER: Prado P 

PROVIDER: S-EPMC10329259 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature