A computational approach for the identification of key genes and biological pathways of chronic lung diseases: a systems biology approach.

ABSTRACT:

Background

Chronic lung diseases are characterized by impaired lung function. Given that many diseases have shared clinical symptoms and pathogenesis, identifying shared pathogenesis can help the design of preventive and therapeutic strategies. This study aimed to evaluate the proteins and pathways of chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), and mustard lung disease (MLD).

Methods and results

After collecting the data and determining the gene list of each disease, gene expression changes were examined in comparison to healthy individuals. Protein-protein interaction (PPI) and pathway enrichment analysis were used to evaluate genes and shared pathways of the four diseases. There were 22 shared genes, including ACTB, AHSG, ALB,

SUBMITTER: Rezaeeyan H 

PROVIDER: S-EPMC10329352 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature