CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitus.

ABSTRACT:

Background

Higher chemokine C-X-C motif ligand 5 (CXCL5) level was observed in type 2 diabetes mellitus (DM) patients; however, its role in diabetic vasculopathy was not clarified. This study aimed to explore the impacts and mechanistic insights of CXCL5 in neovasculogenesis and wound healing in DM.

Methods

Endothelial progenitor cells (EPCs) and human aortic endothelial cells (HAECs) were used in vitro. Streptozotocin-induced diabetic mice and Lepr^db/JNarl mice were used as type 1 and type 2 DM models. Moreover, CXCL5 knockout mice were used to generate diabetic mice. Hindlimb ischemia surgery, aortic ring assays, matrigel plug assay, and wound healing assay were conducted.

Results

CXCL5 concentrations were increased in plasma and EPCs culture medium from

SUBMITTER: Chen C 

PROVIDER: S-EPMC10329364 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature