Unravelling transmission ratio distortion across the bovine genome: identification of candidate regions for reproduction defects.

ABSTRACT:

Background

Biological mechanisms affecting gametogenesis, embryo development and postnatal viability have the potential to alter Mendelian inheritance expectations resulting in observable transmission ratio distortion (TRD). Although the discovery of TRD cases have been around for a long time, the current widespread and growing use of DNA technologies in the livestock industry provides a valuable resource of large genomic data with parent-offspring genotyped trios, enabling the implementation of TRD approach. In this research, the objective is to investigate TRD using SNP-by-SNP and sliding windows approaches on 441,802 genotyped Holstein cattle and 132,991 (or 47,910 phased) autosomal SNPs.

Results

The TRD was characterized using allelic and genotypic parameterizations. Acr

SUBMITTER: Id-Lahoucine S 

PROVIDER: S-EPMC10329377 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature