Porphyromonas gulae and PPAD antibodies are not related to citrullination in rheumatoid arthritis.

ABSTRACT:

Introduction

Porphyromonas gulae have the enzyme PPAD, as P. gingivalis, which is responsible for citrullination related to the pathophysiology of rheumatoid arthritis and periodontitis; this implies the presence of two species of PPAD-producing bacteria in the mouth as well as the presence of citrullinated proteins. There are no previous reports or studies investigating an association between P. gulae PPAD in rheumatoid arthritis (RA).

Objective

To assess the presence of P. gulae and anti-citrullinated peptide antibodies of P. gulae PAD in patients with RA and their possible relationship with clinical activity markers.

Subjects and methods

A total of 95 patients with RA and 95 controls were included. Erythrocyte sedimentation rate (ESR), C-reactive protein, anti-citr

SUBMITTER: Castellar-Mendoza C 

PROVIDER: S-EPMC10329627 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature