The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients.

ABSTRACT:

Background

Delayed gastric emptying has been associated with increased graft rejection, although the mechanism of this association is not known. This study aims to investigate the interrelationship between delays in gastrointestinal motility and the diversity and composition of gastric, oropharyngeal, and lung microbiomes in pediatric lung transplant recipients.

Methods

We prospectively recruited 23 pediatric lung transplant recipients and 98 pediatric patients with respiratory symptoms undergoing combined endoscopy and bronchoscopy. Gastric, oropharyngeal, and bronchoalveolar lavage samples were collected for 16S sequencing. Gastric samples were also analyzed for bile composition using liquid chromatography.

Results

Patients who underwent lung transplantation had sig

SUBMITTER: Lotstedt B 

PROVIDER: S-EPMC10329775 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature