Diet quality, common genetic polymorphisms, and bladder cancer risk in a New England population-based study.

ABSTRACT:

Purpose

We examined the interaction between common genetic bladder cancer variants, diet quality, and bladder cancer risk in a population-based case-control study conducted in New England.

Methods

At the time of enrollment, 806 bladder cancer cases and 974 controls provided a DNA sample and completed a diet history questionnaire. Diet quality was assessed using the 2010 Alternate Healthy Eating Index (AHEI-2010) score. Single nucleotide polymorphisms (SNPs) reported in genome-wide association studies to be associated with bladder cancer risk were combined into a polygenic risk score and also examined individually for interaction with the AHEI-2010. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression.

Results

A 1-standa

SUBMITTER: Leeming RC 

PROVIDER: S-EPMC10329807 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature