Short-term effect of growth hormone treatment in childhood leukemia survivors with growth hormone deficiency.

ABSTRACT:

Purpose

Survivors of childhood leukemia are at risk of growth impairment due to intensive chemotherapy and radiation treatments. This study investigated the auxological and biochemical characteristics of childhood leukemia survivors diagnosed with growth hormone deficiency (GHD) and the changes in these parameters after 1 year of growth hormone (GH) treatment.

Methods

A total of 24 children diagnosed with GHD after leukemia treatment was analyzed. Clinical and biochemical data were collected retrospectively at leukemia diagnosis, GHD diagnosis, and 1 year after GH treatment. Standard deviation score (SDS) was calculated based on the age- and gender-adjusted population.

Results

Of the 24 children included in this study, 19 received GH treatment. The median age at GHD d

SUBMITTER: Shin C 

PROVIDER: S-EPMC10329940 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature