Polydrug use among patients on methadone medication treatment: Evidence from urine drug testing to inform patient safety.

ABSTRACT:

Aims

Patients in methadone medication treatment for opioid use disorder (M-MOUD) typically have a complex history of opioid use, often in combination with other drugs. It is unknown how frequently M-MOUD patients experience persistent substance or polysubstance use. We measured trends in illicit substance use in a large, multistate population of M-MOUD patients and persistence of substance use in the first year of treatment.

Design

Retrospective cohort study of United States (US) M-MOUD patients from 2017 to 2021, focused on urine drug specimens provided for testing to Millennium Health, a third-party laboratory. Specimens were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Generalized estimating equations (GEE) were used to estimate the average tr

SUBMITTER: Saloner B 

PROVIDER: S-EPMC10330099 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature