Myocardial Injury Thresholds for 4 High-Sensitivity Troponin Assays in a Population-Based Sample of US Children and Adolescents.

ABSTRACT:

Background

Myocardial injury is an important pediatric diagnosis. Establishing normative data from a representative pediatric sample is vital to provide accurate upper reference limits (URLs) for defining myocardial injury using high-sensitivity cardiac troponin.

Methods

Among participants 1 to 18 years of age in the 1999-2004 National Health and Nutrition Examination Survey, we measured high-sensitivity troponin T using one assay (Roche) and high-sensitivity troponin I using 3 assays (Abbott, Siemens, and Ortho). In a strictly defined healthy subgroup, we estimated 97.5th and 99th percentile URLs for each assay using the recommended nonparametric method.

Results

Of 5695 pediatric participants, 4029 met criteria for the healthy subgroup (50% males; mean age 12.6 years

SUBMITTER: McEvoy JW 

PROVIDER: S-EPMC10330102 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature