Downfield proton MRSI with whole-brain coverage at 3T.

ABSTRACT:

Purpose

To develop a 3D downfield (DF) MRSI protocol with whole brain coverage and post-processing pipeline for creation of metabolite maps.

Methods

A 3D, circularly phase-encoded version of the previously developed 2D DF MRSI sequence with 13‾31‾$$ 1\overline{3}3\overline{1} $$ spectral-spatial excitation and frequency selective refocusing was implemented and tested in five healthy volunteers at 3T. The DF metabolite maps with a nominal spatial resolution of 0.7 cm³ were recorded in eight slices at 3T in a scan time of 22 m 40 s. An MRSI post-processing pipeline was developed to create DF metabolite maps. Metabolite concentrations and uncertainty estimates were compared between region differences for nine DF peaks.

Results

LCModel analysis showed Cramer Ra

SUBMITTER: Ozdemir I 

PROVIDER: S-EPMC10330175 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature