Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome.

ABSTRACT: T cell-mediated hyperinflammatory responses, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), are now well-established toxicities of chimeric antigen receptor (CAR) T cell therapy. As the field of CAR T cells advances, however, there is increasing recognition that hemophagocytic lymphohistiocytosis (HLH)-like toxicities following CAR T cell infusion are occurring broadly across patient populations and CAR T cell constructs. Importantly, these HLH-like toxicities are often not as directly associated with CRS and/or its severity as initially described. This emergent toxicity, however ill-defined, is associated with life-threatening complications, creating an urgent need for improved identification and optimal management. With the goa

SUBMITTER: Hines MR 

PROVIDER: S-EPMC10330221 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature