Upregulation of TLR5 indicates a favorable prognosis in prostate cancer.

ABSTRACT:

Background

Toll-like receptors (TLRs) are the key sensors of innate immunity for triggering immune responses against infections. TLRs are well known to be expressed and activated in innate immune cells, such as macrophage and dendritic cells, but we and others have found that some TLRs are also functional in epithelial cells. However, the role of an epithelial TLR in prostate cancer remains elusive.

Methods

TLR5 expression in messenger RNA and protein level in prostate cancer was determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC). The activation of TLR5 signaling in epithelial cells was detected upon nuclear factor-κB activation by luciferase assay and western blot analysis, and proinflammatory cytokine activat

SUBMITTER: Liang H 

PROVIDER: S-EPMC10330358 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature