Clonal Hematopoiesis in Young Women Treated for Breast Cancer.

ABSTRACT:

Purpose

Young women treated for breast cancer with cytotoxic therapies are at risk for clonal hematopoiesis of indeterminate potential (CHIP), a condition in which blood cells carrying a somatic mutation associated with hematologic malignancy comprise at least 4% of the total blood system. CHIP has primarily been studied in older patient cohorts with limited clinical phenotyping.

Experimental design

We performed targeted sequencing on longitudinal blood samples to characterize the clonal hematopoietic landscape of 878 women treated for breast cancer enrolled in the prospective Young Women's Breast Cancer Study.

Results

We identified somatic driver mutations in 252 study subjects (28.7%), but only 24 (2.7%) had clones large enough to meet criteria for CHIP. The most co

SUBMITTER: Gibson CJ 

PROVIDER: S-EPMC10330424 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature