Associations between prenatal phthalate exposure and childhood epigenetic age acceleration.

ABSTRACT:

Background

Phthalates, a group of pervasive endocrine-disrupting chemicals found in plastics and personal care products, have been associated with a wide range of developmental and health outcomes. However, their impact on biomarkers of aging has not been characterized. We tested associations between prenatal exposure to 11 phthalate metabolites on epigenetic aging in children at birth, 7, 9, and 14 years of age. We hypothesized that prenatal phthalate exposure will be associated with epigenetic age acceleration measures at birth and in early childhood, with patterns dependent on sex and timing of DNAm measurement.

Methods

Among 385 mother-child pairs from the CHAMACOS cohort, we measured DNAm at birth, 7, 9, and 14 years of age, and utilized adjusted linear regression to as

SUBMITTER: Khodasevich D 

PROVIDER: S-EPMC10330458 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature