Activation of the Aryl Hydrocarbon Receptor in Muscle Exacerbates Ischemic Pathology in Chronic Kidney Disease.

ABSTRACT:

Background

Chronic kidney disease (CKD) accelerates the development of atherosclerosis, decreases muscle function, and increases the risk of amputation or death in patients with peripheral artery disease (PAD). However, the mechanisms underlying this pathobiology are ill-defined. Recent work has indicated that tryptophan-derived uremic solutes, which are ligands for AHR (aryl hydrocarbon receptor), are associated with limb amputation in PAD. Herein, we examined the role of AHR activation in the myopathy of PAD and CKD.

Methods

AHR-related gene expression was evaluated in skeletal muscle obtained from mice and human PAD patients with and without CKD. AHR^mKO (skeletal muscle-specific AHR knockout) mice with and without CKD were subjected to femoral artery ligation,

SUBMITTER: Balestrieri N 

PROVIDER: S-EPMC10330629 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature