Extracellular matrix cues regulate the differentiation of pluripotent stem cell-derived endothelial cells.

ABSTRACT: The generation of endothelial cells (ECs) from human pluripotent stem cells (PSCs) has been a promising approach for treating cardiovascular diseases for several years. Human PSCs, particularly induced pluripotent stem cells (iPSCs), are an attractive source of ECs for cell therapy. Although there is a diversity of methods for endothelial cell differentiation using biochemical factors, such as small molecules and cytokines, the efficiency of EC production varies depending on the type and dose of biochemical factors. Moreover, the protocols in which most EC differentiation studies have been performed were in very unphysiological conditions that do not reflect the microenvironment of native tissue. The microenvironment surrounding stem cells exerts variable biochemical and biomechanical stim

SUBMITTER: Noh KM 

PROVIDER: S-EPMC10330705 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature