In vitro strategies for mimicking dynamic cell-ECM reciprocity in 3D culture models.

ABSTRACT: The extracellular microenvironment regulates cell decisions through the accurate presentation at the cell surface of a complex array of biochemical and biophysical signals that are mediated by the structure and composition of the extracellular matrix (ECM). On the one hand, the cells actively remodel the ECM, which on the other hand affects cell functions. This cell-ECM dynamic reciprocity is central in regulating and controlling morphogenetic and histogenetic processes. Misregulation within the extracellular space can cause aberrant bidirectional interactions between cells and ECM, resulting in dysfunctional tissues and pathological states. Therefore, tissue engineering approaches, aiming at reproducing organs and tissues in vitro, should realistically recapitulate the native cell-

SUBMITTER: Urciuolo F 

PROVIDER: S-EPMC10330728 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature