High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography.

ABSTRACT:

Background

Different observations have suggested that patients with depression have a higher risk for a number of comorbidities and mortality. The underlying causes have not been fully understood yet.

Aims

The aim of our study was to investigate the association of a genetic depression risk score (GDRS) with mortality [all-cause and cardiovascular (CV)] and markers of depression (including intake of antidepressants and a history of depression) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study involving 3,316 patients who had been referred for coronary angiography.

Methods and results

The GDRS was calculated in 3,061 LURIC participants according to a previously published method and was found to be associated with all-cause (p = 0.016) and CV mortal

SUBMITTER: Kramer RM 

PROVIDER: S-EPMC10330785 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature