Sustained modulation of primate deep brain circuits with focused ultrasonic waves.

ABSTRACT:

Background

Transcranial focused ultrasound has the potential to noninvasively modulate deep brain circuits and impart sustained, neuroplastic effects.

Objective

Bring the approach closer to translations by demonstrating sustained modulation of deep brain circuits and choice behavior in task-performing non-human primates.

Methods

Low-intensity transcranial ultrasound of 30 s in duration was delivered in a controlled manner into deep brain targets (left or right lateral geniculate nucleus; LGN) of non-human primates while the subjects decided whether a left or a right visual target appeared first. While the animals performed the task, we recorded intracranial EEG from occipital screws. The ultrasound was delivered into the deep brain targets daily for a period of more t

SUBMITTER: Webb TD 

PROVIDER: S-EPMC10330836 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature