First-in-human prediction of chronic pain state using intracranial neural biomarkers.

ABSTRACT: Chronic pain syndromes are often refractory to treatment and cause substantial suffering and disability. Pain severity is often measured through subjective report, while objective biomarkers that may guide diagnosis and treatment are lacking. Also, which brain activity underlies chronic pain on clinically relevant timescales, or how this relates to acute pain, remains unclear. Here four individuals with refractory neuropathic pain were implanted with chronic intracranial electrodes in the anterior cingulate cortex and orbitofrontal cortex (OFC). Participants reported pain metrics coincident with ambulatory, direct neural recordings obtained multiple times daily over months. We successfully predicted intraindividual chronic pain severity scores from neural activity with high sensitivity usi

SUBMITTER: Shirvalkar P 

PROVIDER: S-EPMC10330878 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature