Synthesis and biological evaluation of biotinylated ZJ-101.

ABSTRACT: ZJ-101 is a structurally simplified analog of marine natural product superstolide A that was previously designed and synthesized in our laboratory. Biological investigation shows that ZJ-101 maintains the potent anticancer activity of the original natural product with an undefined mechanism of action. To facilitate chemical biology study, a biotinylated ZJ-101 was synthesized and biologically evaluated.

SUBMITTER: Qian S 

PROVIDER: S-EPMC10330923 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature