Intra-individual variability in cognitive performance predicts functional decline in Parkinson's disease.

ABSTRACT:

Background

Cognitive deficits contribute to disability in Parkinson's disease (PD). Cognitive intra-individual variability (IIV) is associated with cognitive decline in age-related disorders, but IIV has not been related to functional ability in PD. We examined IIV in predicting functional ability in participants with PD.

Methods

De-identified National Alzheimer's Coordinating Center data (N = 1,228) from baseline and follow-up visits included participants with PD propensity score matched to control participants at baseline on age (M = 72), education (M = 15), and gender (28% female). PD symptom duration averaged 6 years. Outcome measures included the Functional Ability Questionnaire (FAQ), overall test battery mean (OTBM) of ten cognitive variables, IIV

SUBMITTER: Davis JJ 

PROVIDER: S-EPMC10330935 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature