Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection.

ABSTRACT:

Background

In adults with Clostridioides difficile infection (CDI), higher stool concentrations of toxins A and B are associated with severe baseline disease, CDI-attributable severe outcomes, and recurrence. We evaluated whether toxin concentration predicts these presentations in children with CDI.

Methods

We conducted a prospective cohort study of inpatients aged 2-17 years with CDI who received treatment. Patients were followed for 40 days after diagnosis for severe outcomes (intensive care unit admission, colectomy, or death, categorized as CDI primarily attributable, CDI contributed, or CDI not contributing) and recurrence. Baseline stool toxin A and B concentrations were measured using ultrasensitive single-molecule array assay, and 12 plasma cytokines were meas

SUBMITTER: Sandora TJ 

PROVIDER: S-EPMC10330943 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature