Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study.

ABSTRACT:

Introduction

Second-generation integrase strand transfer inhibitors (INSTIs) are preferred treatment options worldwide, and dolutegravir (DTG) is the treatment of choice in resource-limited settings. Nevertheless, in some resource-limited settings, these drugs are not always available. An analysis of the experience with the use of INSTIs in unselected adults living with HIV may be of help to make therapeutic decisions when second-generation INSTIs are not available. This study aimed to evaluate the real-life effectiveness and safety of dolutegravir (DTG), elvitegravir/cobicistat (EVG/c), and raltegravir (RAL) in a large Spanish cohort of HIV-1-infected patients.

Methods

Real-world study of adults living with HIV who initiated integrase INSTIs DTG, EVG/c, and RAL-based regime

SUBMITTER: Santos JR 

PROVIDER: S-EPMC10331300 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature